The Italian Space Agency (Italian: Agenzia Spaziale Italiana; ASI) is a government agency established in 1988 to fund, regulate and coordinate space exploration activities in Italy. The agency cooperates with numerous national and international entities who are active in aerospace research and technology.

Nationally, ASI is responsible for both drafting the National Aerospace Plan and ensuring it is carried out. To do this the agency operates as the owner/coordinator of a number of Italian space research agencies and assets such as CIRA as well as organising the calls and opportunities process for Italian industrial contractors on spaceflight projects. Internationally, the ASI provides Italy's delegation to the Council of the European Space Agency and to its subordinate bodies as well as representing the country's interests in foreign collaborations.

ASI's main headquarters are located in Rome, Italy, and the agency also has direct control over two operational centres: the Centre for Space Geodesy (CGS) located in Matera in Italy, and its own spaceport, the Broglio Space Centre (formerly the San Marco Equatorial Range) on the coastal sublittoral of Kenya, currently used only as a communications ground station. One further balloon launch base located in Trapani was permanently closed in 2010. In 2020, ASI's annual revenues budget was approximately €2.0 billion and it directly employed around 200 workers.